Autophagy: Regulation by Energy Sensing
نویسندگان
چکیده
Autophagy is inhibited by the mTOR signaling pathway, which is stimulated by increased amino acid levels. When cellular energy production is compromised, AMP-activated protein kinase is activated, mTOR is inhibited and autophagy is stimulated. Two recent studies have shed light on the molecular mechanism by which AMPK controls autophagic flux.
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عنوان ژورنال:
- Current Biology
دوره 21 شماره
صفحات -
تاریخ انتشار 2011